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If you want to use an antacid for an upset stomach, make sure it is at least 2 hours since you last took tetracycline, or 4 hours before your next dose.

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With renal impairmenttetracycline should be avoided because it can cause further deterioration of kidney function and the drug tends to accumulate in the serum12 Tetracycline is slowly removed by hemodialysisbut not very well by peritoneal dialysis13 Caution is advised in administering tetracycline in patients with hepatic impairment because this may result in liver damage.

Do not take iron supplementsmultivitaminscalcium supplementsantacidsor laxatives within 2 hours before or after taking tetracyclineThese products can make tetracycline less effective.

There’s a lag period of one to three weeks between the change in dosage and its effect on skinIf the skin problem becomes worsereturn to the previous higher dosage and continue on it or as advised by your doctor.

There are three naturally occurring tetracyclinesoxytetracyclinechlortetracyclineand demethylchlortetracyclineand several that are derived semisyntheticallytetracyclinerolitetracyclinemethacyclineminocyclinedoxycyclinelymecyclineetcElimination times permit a further classification into short-actingtetracyclineoxytetracyclinechlortetracyclineintermediate-actingdemethylchlortetracycline and methacyclineand long-actingdoxycycline and minocyclineThe newest class of tetracyclinerelated antimicrobials are the glycylcyclinesrepresented by tigecyclinewhich contains a bulky side chain compared with minocycline

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the ft-ir spectra of treated tetracycline showed the vibrational peaks at 3342-3325 cm -1 that were attributed to n-h and o-h stretching.