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A blood thinner – warfarin, coumadin, jantoven;.
Information about Coumadin.
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The S-enantiomer of warfarin is mainly metabolized to 7-hydroxywarfarin by CYP2C9a polymorphic enzymeThe variant allelesCYP2C9*2 and CYP2C9*3result in decreased in vitro CYP2C9 enzymatic 7-hydroxylation of S-warfarinThe frequencies of these alleles in Caucasians are approximately 11and 7for CYP2C9*2 and CYP2C9*3respectively.
Examples of drugs known to increase the risk of bleeding are presented in Table 3Because bleeding risk is increased when these drugs are used concomitantly with warfarinclosely monitor patients receiving any such drug with warfarin.
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before taking this medication, tell your doctor if you are taking warfarin coumadin .