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Hmodialysis : Whil studis hav not bn conductd in patints with nd-stag nal disas, hmodialysis is not xpctd tsigniicantly nhanc claanc atovastatin sinc th dug is xtnsivly bound tplasma potins.
Colchicin: Cass myopathy, including habdomyolysis, hav bn potd with atovastatin co-administd with colchicin, and caution should b xcisd whn pscibing ATOLIP CV with colchicin.
Thombolytics: Th saty th concomitant administation clopidogl, ibin non-ibin spciic thombolytic agnts and hpains was assssd in patints with acut myocadial inaction. Th incidnc clinically signiicant blding was simila tthat obsvd whn thombolytic agnts and hpain a co-administd with aspiin.
Myopathy should b considd in any patint with dius myalgias, muscl tndnss waknss, and/makd lvation CPK. Patints should b advisd tpot pomptly unxplaind muscl pain, tndnss, waknss, paticulaly i accompanid by malais v i muscl signs and symptoms psist at discontinuing ATOLIP CV . ATOLIP CV thapy should b discontinud i makdly lvatd CPK lvls occu myopathy is diagnosd suspctd.
A cass habdomyolysis with acut nal ailu sconday tmyoglobinuia hav bn potd with atovastatin and with oth dugs in this class. A histoy nal impaimnt may b a isk actth dvlopmnt habdomyolysis. Such patints mit clos monitoing skltal muscl cts.
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all patients starting therapy with atorlip should be advised of the risk of myopathy and told to report promptly any unexplained muscle pain, tenderness, or weakness.