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There is thus made available a particularly effective antimicrobial combination of the broad-spectrum antibiotic Terramycin as well as polymyxin B sulfate against primarily causative or secondarily infecting organisms.
Up to 44 percent of strains of Streptococcus pyogenes and 74 percent of Streptococcus faecalis have been found to be resistant to tetracycline drugsThereforetetracyclines should not be used for streptococcal disease unless the organism has been demonstrated to be sensitive.
If renal impairment existseven usual oral or parenteral doses may lead to excessive systemic accumulation of the drug and possible liver toxicityUnder such conditionslower than usual total doses are indicated andif therapy is prolongedserum level determinations of the drug may be advisableThis hazard is of particular importance in the parenteral administration of tetracyclines to pregnant or postpartum patients with pyelonephritisWhen used under these circumstancesthe blood level should not exceed 15 mcg/ml and liver function tests should be made at frequent intervalsOther potentially hepatotoxic drugs should not be prescribed concomitantly.
Bulging fontanels in infants and benign intracranial hypertension in adults have been reported in individuals receiving full therapeutic dosagesThese conditions disappeared rapidly when the drug was discontinued.
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the reversal of the toxicity of oxytetracycline terramycin by multivalent cations.