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Appropriate monitoring and advice are required for patients with a history of hypertension and/or mild to moderate congestive heart failure as fluid retention and oedema have been reported in association with NSAID therapy.
Serious gastrointestinal adverse effects such as bleedingulceration and perforationwhich can be fatalhas been reported and can occur at any time with or without warning symptoms in patients treated with NSAIDs or a previous history of serious GI eventsIf any sign of gastrointestinal bleeding occursLodine should be stopped immediately.
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