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Of these patients, 157 were treated with combivent respimat.
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Additional side effects identified from the published literature and/or post-marketing surveillance on the use of ipratropium bromide-containing productssingly or in combination with albuterolincludehypersensitivitypharyngeal edemamouth edemaurinary retentionmydriasisbronchospasmincluding paradoxical bronchospasmcases of precipitation or worsening of narrow-angle glaucomaglaucomaintraocular pressure increasedacute eye painhalo visionblurred visionaccommodation disorderocular irritationcorneal edemaconjunctival hyperaemianasal congestiondrying of secretionsmucosal ulcersstomatitisirritation from aerosolthroat irritationdry throatwheezingexacerbation of COPD symptomshoarsenesspalpitationsheartburndrowsinessCNS stimulationcoordination difficultyflushingalopeciahypotensionedemagastrointestinal distressdiarrheanauseavomitinggastrointestinal motility disorderconstipationhypokalemiamental disorderhyperhidrosismuscle spasmsmuscular weaknessmyalgiaastheniamyocardial ischemiadiastolic blood pressure decreasedand systolic blood pressure increased.
Additional side effects identified from the published literature and/or post-marketing surveillance on the use of ipratropium bromide-containing productssingly or in combination with albuterolincludehypersensitivitypharyngeal edemamouth edemaurinary retentionmydriasisbronchospasmincluding paradoxical bronchospasmcases of precipitation or worsening of narrow-angle glaucomaglaucomaintraocular pressure increasedacute eye painhalo visionblurred visionaccommodation disorderocular irritationcorneal edemaconjunctival hyperaemianasal congestiondrying of secretionsmucosal ulcersstomatitisirritation from aerosolthroat irritationdry throatwheezingexacerbation of COPD symptomshoarsenesspalpitationsheartburndrowsinessCNS stimulationcoordination difficultyflushingalopeciahypotensionedemagastrointestinal distressdiarrheanauseavomitinggastrointestinal motility disorderconstipationhypokalemiamental disorderhyperhidrosismuscle spasmsmuscular weaknessmyalgiaastheniamyocardial ischemiadiastolic blood pressure decreasedand systolic blood pressure increased.
Albuterol is longer acting than isoproterenol in most patients because it is not a substrate for the cellular uptake processes for catecholamines nor for metabolism by catechol-O-methyl transferaseInsteadthe drug is conjugatively metabolized to albuterol 4O-sulfate.
Because of the potential for tumorigenicity shown for albuterol in animal studiesa decision should be made whether to discontinue nursing or to discontinue the drugtaking into account the importance of the drug to the mother.
Metabolic acidosis has been reported with use of albuterol-containing products.
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the drug product, combivent respimat, iscomposed of a sterile, aqueous solution of atrovent ls bromide andalbuterol sulfate filled into a 4.