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Precautions in special patient populationsCareful dose titration of LIORESAL INTRATHECAL is needed when spasticity is necessary to sustain upright posture and balance in locomotion or whenever spasticity is used to obtain optimal function and care.

Limited pharmacokinetic data suggest that a lumbar-cisternal concentration gradient of about 4:1 is established along the neuroaxis during baclofen infusionThis is based upon simultaneous CSF sampling via cisternal and lumbar tap in 5 patients receiving continuous baclofen infusion at the lumbar level at doses associated with therapeutic efficacythe interpatient variability was greatThe gradient was not altered by position.

The precise mechanism of action of baclofen as a muscle relaxant and antispasticity agent is not fully understoodBaclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal levelpossibly by decreasing excitatory neurotransmitter release from primary afferent terminalsalthough actions at supraspinal sites may also occur and contribute to its clinical effectBaclofen is a structural analog of the inhibitory neurotransmitter gamma-aminobutyric acidGABAand may exert its effects by stimulation of the GABA B receptor subtype.

LABORATORY TESTS No specific laboratory tests are deemed essential for the management of patients on LIORESAL INTRATHECAL.

Take this medication by mouth with or without food as directed by your doctorusually 3 times a dayTo reduce your risk of side effectsyour doctor may direct you to start this medication at a low dose and gradually increase your doseFollow your doctor’s instructions carefully.

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