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This procedure is usually followed by daily doses of naltrexone for up to 12 months.
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In some individuals the use of opioid antagonists has been associated with a change in baseline levels of some hypothalamicpituitaryadrenalor gonadal hormonesThe clinical significance of such changes is not fully understood.
If a more rapid transition from agonist to antagonist therapy is deemed necessary and appropriate by the healthcare providermonitor the patient closely in an appropriate medical setting where precipitated withdrawal can be managed.
Lethargy and somnolence have been reported following doses of REVIA and thioridazine.
Adverse eventsincluding withdrawal symptoms and deathhave been reported with the use of REVIA in ultra rapid opiate detoxification programsThe cause of death in these cases is not knownsee WARNINGS
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the usual dose of naltrexone for alcohol dependence is 50 mg daily, although a few patients may require only 25 mg daily.