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The information below is derived from a clinical trial database for olanzapine consisting of 8661 patients with approximately 4165 patient-years of exposure to oral olanzapine and 722 patients with exposure to intramuscular olanzapine for injection.
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Orthostatic hypotensionlow blood pressure upon standing after lying down or sittinglack of energy dry mouth increased appetite tiredness tremorshakesconstipationhard or infrequent stoolsdizziness restlessness changes in behavior that might be considered offensive to others weight gain.
Very stiffrigidmuscleshigh fevertremorssweatingconfusionfast or uneven heartbeatsslow heart ratefeeling like you might pass outtwitching or uncontrollable movements of your eyeslipstonguefacearmsor legstrouble speaking or swallowingdry mouththirstfeeling very hotwith or without sweatingurinating less than usual or not at allhigh blood sugarincreased thirstloss of appetitefruity breath odorincreased urinationdrowsinessdry skinnauseaand vomitingsudden numbness or weaknessconfusionor problems with visionspeechor balancefeverchillsbody achesflu symptomssores in your mouth and throatswelling in your hands or feetchanges in personalityunusual thoughts or behaviorhallucinationsor thoughts about hurting yourselfor upper stomach painitchingloss of appetitedark urineclay-colored stoolsjaundiceyellowing of the skin or eyes
When more than one factor is present which might result in slower metabolismfemale gendergeriatric agenon-smoking statusconsideration should be given to decreasing the starting doseDose escalationwhen indicatedshould be conservative in such patients.
In narrow-angle glaucomacardiovascular dis easecerebrovascular diseaseprostatic hypertrophyhypovolemiaand dehydrationhyperglycemia may occur and in some cases may be extremeresulting in ketoacidosishyperosmolar comaor deathIM administration of greater than 1 injection is associated with substantial orthostatic hypotension33maintain patient in recumbent position and monitor blood pressure before repeating IM doses.
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national pregnancy registry for atypical antipsychotics there is a pregnancy registry for women who take antipsychotic medications, such as olanzapine.