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Data SynthesisBupropion inhibits the re-uptake of norepinephrine and dopamine neurotransmission without any significant direct effects on serotonin neurotransmissionBupropion is an effective antidepressant with efficacy comparable to selective serotonin reuptake inhibitors and other antidepressantsIt is well tolerated in short-and longer-term treatmentHeadachedry mouthnauseainsomniaconstipationand dizziness are the most common adverse eventsSeizure and allergic reactions are medically important adverse events associated with bupropion and are reported rarelyAmong all the newer antidepressants in the United Statesbupropion appears to have among the lowest incidence of sexual dysfunctionweight gainand somnolenceAlthough not U.SFood and Drug Administration approved for these indicationsbupropion has also been used as an adjunctive treatment to reverse antidepressant-induced sexual dysfunction and to augment anti-depressant efficacy in partial responders and non-responders to other agents.
Dry mouthnauseastomach painheadachedizzinessringing in your earsloss of interest in sexsore throatmuscle painmild itching or skin rashincreased sweatingincreased urinationor changes in appetiteweight loss or gain.
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