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Phenergan is not recommended for use during pregnancy.
Information about Phenergan.
It is unknown if promethazine passes into breast milkIt may have undesirable effects on a nursing infantConsult your doctor before breast-feeding.
During pregnancythis medication should be used only when clearly neededDiscuss the risks and benefits with your doctor.
Parenteral25 mg IV or IMfollowed by close observation for responseThis dose may be repeated within 2 hours if neededOral therapy should be started as soon as feasible if continued medication is required.
CNS DepressantsPhenergan Tablets and Suppositories may increaseprolongor intensify the sedative action of other central-nervous-system depressantssuch as alcoholsedatives/hypnoticsincluding barbituratesnarcoticsnarcotic analgesicsgeneral anestheticstricyclic antidepressantsand tranquilizersthereforesuch agents should be avoided or administered in reduced dosage to patients receiving promethazine HClWhen given concomitantly with Phenergan Tablets and Suppositoriesthe dose of barbiturates should be reduced by at least one-halfand the dose of narcotics should be reduced by one-quarter to one-halfDosage must be individualizedExcessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with painthese symptoms usually disappear with adequate control of the pain.
A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant SyndromeNMShas been reported in association with promethazine HCl alone or in combination with antipsychotic drugsClinical manifestations of NMS are hyperpyrexiamuscle rigidityaltered mental status and evidence of autonomic instabilityirregular pulse or blood pressuretachycardiadiaphoresis and cardiac dysrhythmias
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if there is a need to consider phenergan during your pregnancy, your pharmacist or doctor will discuss with you the benefits and risks of taking it.